Last updated on October 22nd, 2019 at 01:37 pm

Conditions & Symptoms

In recent years, a growing volume of disciplined medical research has emerged regarding the use of medical cannabis as a treatment method for conditions allowed under the Texas Compassionate Use Program: Epilepsy and other seizure disorders, autism spectrum disorder, multiple sclerosis and spasticity, cancer and palliative care, and neurodegenerative diseases.

This research, coupled with an increasing volume of positive results, has led to expanded interest among patients and growing receptivity among physicians for the use of medical cannabis as a part of their prescription regimes.

Explore the tabs below, broken out by legally-approved conditions for the state of Texas. Within each condition, you will be able to browse a variety of current research and clinical trials.

About Formulations

Most clinical studies on medical cannabis are focused on formulations or ratios of the cannabinoids CBD and THC. For the medical conditions approved by the state of Texas Compassionate Use Program, two primary medicine formulations are appropriate:

  • HIGH-CBD FORMULATION
  • BALANCED FORMULATION

It is important to note that different ratios of CBD:THC have been used to treat different symptoms and conditions (see chart).

EPILEPSY

In the case of epilepsy, new medications are desperately needed as 30%–40% of people with epilepsy do not respond to traditional medication regimens. There is also a great deal of concern from patients and their families about the long-term effects of chronic anti-epilepsy drug use.

Fortunately, multiple randomized, placebo-controlled trials indicate both the safety and efficacy of medical cannabis for the treatment of epilepsy.

Epilepsy Symptoms Recommended Formulations

  • SEIZURESHigh-CBD Formulation
  • ANXIETY | High-CBD Formulation

Seizure Management Resources

• Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome  |  Read More

• Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome: a randomized, double-blind, placebo-controlled phase 3 trial  |  Read More

• Effect of Cannabidiol on drop seizures in the Lennox-Gastaut Syndrome  |  Read More

 

Other Epilepsy Resources 

• Perceived Efficacy Of Cannabidiol-enriched Cannabis Extracts For Treatment Of Pediatric Epilepsy  |  Read More

• Cannabinoids and Epilepsy  |  Read More

• CBD-enriched Medical Cannabis For Intractable Pediatric Epilepsy  |  Read More

• Efficacy Of Artisanal Preparations Of Cannabidiol For The Treatment Of Epilepsy  |  Read More

• Efficacy Of CBD-enriched Medical Cannabis For Treatment Of Refractory Epilepsy In Children  |  Read More

MULTIPLE SCLEROSIS / SPASTICITY

Recent studies indicate there is expanding acceptance of cannabis within the MS community. While there are many uncertainties about the overall effects associated with cannabis use in patients with MS, research shows cannabis strains, containing CBD levels equal or higher than THC, have had positive effects on muscle spasticity and pain. The effects of cannabis, and its safety, have been  reviewedby the American Academy of Neurology in a practice guideline. 

Multiple Sclerosis & Spasticity Symptoms Recommended Formulations

  • ANXIETY | High-CBD Formulation
  • PAIN | Balanced Formulation
  • MUSCLE SPASM | Balanced Formulation

Clinical Trial Results

• Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial  |  Read More

• Randomized Controlled Trials of Cannabis-Based Medicine in Spasticity Caused by Multiple Sclerosis  |  Read More

Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis  |  Read More

• Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients​.  |  Read More

AUTISM

Access to medical cannabis use for the treatment of Autism Spectrum Disorder (ASD) symptoms was preceded by treatment of epilepsy symptoms. Research showed the initial use by patients with epilepsy had improvement in anxiety, aggression, panic, tantrums, and self-injurious behaviors. This caused parents of children with ASD to seek out cannabis treatment in hopes of achieving the same results.

Autism Symptoms Recommended Formulations

  • DEPRESSIONHigh-CBD Formulation
  • SEIZURES | High-CBD Formulation
  • RESTLESSNESSHigh-CBD Formulation
  • AGGRESSION & DISRUPTIVE BEHAVIOR | High-CBD Formulation
  • INSOMNIA Balanced Formulation
  • TICSBalanced Formulation

Human-Based Clinical Trial Results

• Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities  |  Read More

• Cannabidiol Based Medical Cannabis in Children with Autism- a Retrospective Feasibility Study  |  Read More

• Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy  |  Read More

• ​Ethical Implications for Providers Regarding Cannabis Use in Children With Autism Spectrum Disorders​  |  Read More

TERMINAL CANCER

There is an increased interest in the use of cannabinoids in the treatment of symptoms in cancer and palliative care patients, including pain, loss of appetite, anxiety, insomnia and nausea. In 2016, The American Society of Clinical Oncology published guidelines to help cancer survivors manage chronic pain. These recommendations included the use of medical cannabis and cannabinoid-based medicines. 

Terminal Cancer Symptoms Recommended Formulations

  • ANXIETYHigh-CBD Formulation
  • PAINBalanced Formulation
  • APPETITE LOSS | Balanced Formulation
  • INSOMNIA | Balanced Formulation
  • NAUSEABalanced Formulation

Clinical Trial Results

• Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain  |  Read More

• An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics  |  Read More

 

Human Trial Results

• Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience  |  Read More

 

Other Articles of Interest

• ​Cannabinoids as therapeutic agents in cancer: current status and future implications  |  Read More

• Cannabis in palliative care: current challenges and practical recommendations  |  Read More

• Choice of opioids and the WHO ladder  |  Read More

• Update on prevalence of pain in patients with cancer: Systematic review and meta-analysis  |  Read More

• Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems: A Clinical Review  |  Read More

• Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline  |  Read More

• Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience  |  Read More

• Flavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer  |  Read More

ALS

Some studies indicate use of medical cannabis slows the progress of neurodegeneration. Medical cannabis may improve the quality of life for individuals with amyotrophic lateral sclerosis symptoms by improving appetite and sleep, while decreasing pain and spasticity.

ALS Symptoms Recommended Formulations

  • APPETITE LOSS | High-CBD Formulation & Balanced Formulation
  • PAINBalanced Formulation
  • SPASTICITYBalanced Formulation

Clinical Trial Results

• Survey of cannabis use in patients with amyotrophic lateral sclerosis |  Read More

 

Other Articles of Interest

• Cannabis and ALS: Hypothetical and Practical Applications, and a Call for Clinical Trials   |  Read More

• Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?   |  Read More

• Pros and Cons of Medical Cannabis use by People with Chronic Brain Disorders   |  Read More

• Endocannabinoids and amyotrophic lateral sclerosis   |  Read More

 

Research On Symptoms Related to ALS

• ​Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?  |  Read More

• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors  |  Read More

• Randomized Controlled Trials of Cannabis-Based Medicine in Spasticity Caused by Multiple Sclerosis  |  Read More

• Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial  |  Read More

• Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis  |  Read More

Are we missing a valuable article? Want to contribute to our resources?

Conditions, Symptoms & Recommended Formulations

Use the chart below to cross reference specific conditions with associated symptoms and the recommended formulation for treatment.

SymptomsEpilepsyAutismMultiple SclerosisSpasticityTerminal CancerALS
AnxietyHigh-CBDHigh-CBDHigh-CBD
DepressionHigh-CBD
SeizuresHigh-CBDHigh-CBD
RestlessnessHigh-CBD
Disruptive BehaviorHigh-CBD
PainBalancedBalancedBalancedBalanced
Appetite LossBalancedBalanced
Muscle SpasmsBalancedBalancedBalanced
InsomniaBalancedBalanced
NauseaBalanced
TicsBalanced

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